"License to kill" reflects joint action of CD4 and CD8 T cells.

Ratio of CD4+ to CD8+ T-Cells in the Recent Reported Cases of Bird Flu Infection in Asia

Numerical status of CD4+CD25+FoxP3+ and CD8+CD28- regulatory T cells in multiple sclerosis

Objective(s): Regulatory T cells, including CD4+CD25+Fox3+ and CD8+CD28- cells play an important role in regulating the balance between immunity and tolerance. Since multiple sclerosis is an inflammatory autoimmune disease, regulatory T cells are considered to be involved in its pathogenesis. In this study, we investigated the circulatory numbers of the two mentioned types of regulatory T cells...

Comparative Analysis of CD4+ and CD8+ T Cells in Tumor Tissues, Lymph Nodes and the Peripheral Blood from Patients with Breast Cancer

Background: CD4+ and CD8+ T cells are the main types of lymphocytes in cell-mediated immunity and play a central role in the induction of efficient immune responses against tumors. The frequencies of T cell subtypes in the peripheral blood and tumor tissues, and draining lymph nodes (dLN) can be considered as useful markers for evaluation of the immune system in cancers. Methods: In this study,...

The effects of anti-Fas ribozyme on T lymphocyte apoptosis in mice model with chronic obstructive pulmonary disease

Objective(s): In this study, we aimed to investigate the effects of anti-Fas ribozyme on the apoptosis of T lymphocytes (T cells) in mice model with chronic obstructive pulmonary disease (COPD). Materials and Methods: Male 6-week-old C57BL/6 mice were used to establish the COPD model by exposure to cigarette smoke. The COPD mice were sacrificed for spleen dissection and T cell isolation. T cell...

سطح بالای پاسخ ایمنی اختصاصی لنفوسیت‌های CD4+وCD8+ نسبت به سیتومگالوویروس و همبستگی بین آن‌ها در بیماران مبتلا به لوسمی لنفوسیتی مزمن سلولB

  High level of CMV-specific CD4+ and CD8+cells Immune Response and Correlation Between them in B-cell Chronic Lymphocytic Leukemia Patients     B. Pourgheysri [1] , P. Moss [2]     Received: 10/09/07 Sent for Revision: 05/03/08 Received Revised Manuscript: 06/12/08 Accepted: 30/12/08   Background and Objective: Chronic lymphocytic leukemia (CLL) is characterized by a monoclonal proliferation o...